M.H. Al-Nazawi and A.M. Homeida*
Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine and Animal Resources,
*Camel Research Centre, King Faisal University, P.O. Box 3498, Al-Ahsa 31982, Saudi Arabia
ABSTRACT
The comparative serum pharmacokinetics of Enrofloxacin (E) and Marbofloxacin (M) were determined following an intramuscular dose of 5 mg/kg and 2.5 mg/kg body weight, respectively in camels. The data obtained was best fitted to 2-compartment open model. The maximum peak concentration of Enrofloxacin was 2.6 μg/ml and Marbofloxacin was 1.7 μg/ml obtained after 1.93 and 1.80 hours, respectively. The
t½ was 4.03 for Enrofloxacin and 7.1 hours for Marbofloxacin. The t½, MRT and AUC were significantly greater for marbofloxacin than enrofloxacin.
Key words: Camel, Enrofloxacin, intramuscular, Marbofloxacin, pharmacokinetics
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