Atif E. Abdel Gadir1, Mubark Abdel Rahman2, Intisar E. EL Rayah2 and Khitma H. Elmalik1
1Department of Preventive Medicine & Public Health, Faculty of Veterinary Medicine, University of
Khartoum, P.O. Box 32, Khartoum, Sudan
2Tropical Medicine Research Institute (TMRI), National Centre Research (NCR),
P.O. Box 1304, Kartoum 11111, Sudan
ABSTRACT
A total of 126 mice were used to study drug resistance on 13 isolates of Trypanosoma evansi collected from Butana, Gadarif and Southern Kordofan state against Quinapyramine sulphate and Cymelarsan. For Quinapyramine sulphate, 36 mice (6 control and 6 tested group for each state) were used (the drug was given S/C), the results revealed that the isolates were very sensitive in Southern Kordofan state. 6 mice were cured, however, the isolates showed resistance to the drug in all mice (12 mice) infected with T. evansi in Butana and Gadarif state. Regarding Cymelarsan, 36 mice (6 control and 6 tested group for each state) were used (the drug was given S/C), the results showed that the isolates were very sensitive in Southern Kordofan and Gadarif state. All mice were cured, but the isolates showed some degree of resistance in Butana (4 out of 6 isolates were cured).
Key words: Camel, drug resistance, Sudan, trypanosomosis
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