M Oukessou1*, MR Achaaban2, JF Sutra3 and M Alvinerie3
1Department of Physiology and Therapeutics, 2 Department of Comparative Anatomy,
Hassan II Agronomic and Veterinary Institute, PO Box 6202, Rabat, Morocco and
3Station de Pharmacologie et Toxicologie, INRA, Toulouse, France.*
ABSTRACT
The present study was conducted to investigate the effect of the administration site on the plasma kinetics of eprinomectin in five dromedary camels following a single pour-on administration (0.500 mg/kg bw). Three camels received uniformly the drug along the dorsal line, from the base of the tail to the withers, including hump whereas the others received the drug dose half administered in the withers region while the other half was given in the croup zone.
The obtained results showed that the peak plasma concentration (Cmax) was about two-fold higher and the area under plasma concentration curve (AUC) increased by 64% when the hump was excluded from the site of administration.
Key words: Camel, dromedary, eprinomectin, pharmacokinetics