The structural organization of chromatosomes (nucleosomes), the subunit of chromatin, (i.e. DNA and histone proteins as occurring in the nucleus of eukaryotes) was investigated for the Ph D dissertation. This topic remained the main research focus afterwards as well and led to several publications in Nucleic Acids Research, J. Mol. Biol, Biochemistry, J.Biol. Chem and a publication in Nature (1998).
3. Details of current employment
Responsible for courses on ‘Immunochemistry’, ‘Recombinant antibody technology’, ‘Applied Immunology’, ‘Analytical Biochemistry’, ‘Nucleic acid chemistry and genetic engineering’, ‘Combinatorial biochemistry and high throughput techniques’, ‘Biotechnology’ (~300 hours/year).
5. Grants held over the last years
7. Five most relevant publications of career
1. Hamers-Casterman C., Atarhouch T., Muyldermans S., Hamers C., Robinson G., BaiyanaSonga E., Bendahman N., &Hamers R.
Naturally occurring antibodies devoid of light chains
Nature363, 446-448, 1993. (3008 citations Google scholar, October 2021)
2. Muyldermans S.
Nanobodies – Natural single domain antibodies.
Ann Rev Biochem82, 775-797, 2013 (IF 34.3) (1368 citations Google scholar, October 2021)
3. Ghahroudi A M., Desmyter A., Wyns L., Hamers R., Muyldermans S.
Selection and identification of single domain antibody fragments from camel heavy-chain antibodies.
FEBS Letters414, 521-526, 1997.(921 citations Google scholar, October 2021)
4. Muyldermans S., Atarhouch T., Saldanha J., Barbosa JARG, Hamers R..
Sequence and structure of VH domain from naturally occurring camel heavy chain immunoglobulins lacking light chains.
Protein Engineering7, 1129-1135, 1994. (618 citations Google Scholar, October 2021)
5. Jovcevska I, Muyldermans S.
The therapeutic potential of Nanobodies.
BioDrugs34 (1): 11-26, 2020January 28. (182 citations, Google scholar October 2021