PHARMACOKINETICS OF CEFQUINOME AFTER SINGLE INTRAMUSCULAR ADMINISTRATION IN DROMEDARY CAMEL (Camelus dromedarius)
Journal Year: 2019
Journal Month: December
Published On: 29-01-2020 07:16:00
Article DOI: 10.5958/2277-8934.2019.00035.3

Lakshmi Kant1, Amita Ranjan1, Rakesh Ranjan2, VK Dumka3 and Rajdeep Kaur3
1Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science,
Rajasthan University of Veterinary and Animal Sciences, Bikaner 334001, Rajasthan, India
2ICAR-National Research Centre on Camel, Jorbeer, Bikaner 334001, Rajasthan, India
3Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences,
Guru Angad Dev Veterinary and Animal Sciences, Ludhiana 141004, Punjab, India


ABSTRACT


The objective of this study was to investigate the pharmacokinetics of cefquinome in 5 healthy male dromedary camels following a single intramuscular (IM) administration at the dose rate of 1 mg/kg body weight in the caudal cervical epiaxial muscles. Blood samples were collected prior to drug administration and up to 48 h after drug administration. No clinical symptoms or signs suggestive of adverse drug reaction could be recorded in any animal. Plasma cefquinome concentration was estimated by high-performance liquid chromatography. The disposition kinetics of cefquinome best fitted to a 2 compartment open model. The peak plasma cefquinome concentration (Cmax cal) of 1.013 ± 0.038 μg/ml–1 was achieved at 5.257 ± 0.067 h (tmax cal). The absorption half-life (t½ka), elimination half-life (t½β), area under plasma drug concentration-time curve (AUC) and apparent volume of distribution (Vdarea) of cefquinome were 3.401 ± 0.042 h, 3.754 ± 0.072 h, 14.417 ± 0.621 μg/ml–1 h and 0.379 ± 0.016 l/kg–1, respectively. The results of the present study suggested that an intramuscular dosage regimen of 1 mg/kg body weight at 24 h interval would maintain the plasma drug levels required to be effective against the common bacterial pathogens in dromedary camel.
Key words: Camel, Cefquinome, Intramuscular, Pharmacokinetics


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