INFLUENCE OF BOKHI ON KIDNEY-YANG-DEFICIENCY SYNDROME IN RATS
Journal Year: 2017
Journal Month: December
Published On: 03-09-2018 18:58:00
Article DOI: 10.5958/2277-8934.2017.00048.0

Z.X. Wang1, Y.Y. Shao2, L. Ming1, L. Yi1 and R. Ji1,3
1Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, College of Food Science and Engineering,
Inner Mongolia Agricultural University, Hohhot 010018, Inner Mongolia, P. R. China
2College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’ an 710119, Shaanxi, P. R. China
3Camel Research Institute of Inner Mongolia, Alashan 737300, Inner Mongolia, P.R. China

ABSTRACT

In Mongolian folk medicine, Bokhi, which comes from male camel occipital gland secretions, is used to treat Kidney-Yang-Deficiency Syndrome (KYDS) which has similar clinical signs as glucocorticoid withdrawal syndrome. Model KYDS rats were established by multipoint subcutaneous injection of hydrocortisone for 14 successive days and then the rats were treated by oral administration of Bokhi from two regions in China and at both a high and a low dose for a further 14 successive days. The growth rate, food intake, urine volume, vesicula seminalis, spleen, kidney, testes and the general condition of rats were recorded. The levels of serum creatinine, blood urea nitrogen, testosterone, thyroid stimulating hormone, superoxide dismutase and nitric oxide in rat serum were quantified. Results demonstrated that the symptoms of KYD were gradually alleviated by the administration of Bokhi, which also affected urine volume. Bokhi increased the growth rate and levels of testesterone, superoxide dismutase and nitric oxide. The levels of serum creatinine, blood urea nitrogen, thyroid stimulating hormone were reduced. However, Bokhi had little effect on food intake or organ indices. This experiment demonstrated that high doses of Bokhi could improve KYDS.
Key words: Camel, Bokhi, KYDS, Hydrocortisone, Occipital gland secretion


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