TRANSCRIPTOME ALTERATIONS IN HIGH GLUCOSE-INDUCED RENAL TUBULAR CELLS OF BACTRIAN CAMEL
Journal Year: 2020
Journal Month: December
Published On: 02-01-2021 11:40:00
Article DOI: 10.5958/2277-8934.2020.00041.7

Bin Yang¶1, Lihui Chen¶1, Xin Li2, Zhuwei Guo1, Shi Liu3 and Demtu Er*1
1College of Veterinary Medicine, Inner Mongolia Agricultural University, Key Laboratory of Clinical Diagnosis and
Treatment Technology in Animal Disease, Ministry of Agriculture, Ministry of Agriculture and
Rural Affairs of P. R. China, Hohhot, Inner Mongolia Autonomous Region, 010011, China
2Animal disease prevention and control centre of Urad Back Banner,
Bayannur city, 015543, Inner Mongolia Autonomous Region, P. R. China
3Animal disease prevention and control centre of Alxa Left Banner,
Bayanhot, 750300, Inner Mongolia Autonomous Region, P. R. China
ABSTRACT


The transcriptome alterations in renal tubular cells of Bactrian camel treated with high glucose were investigated. Primary tubular epithelial cells, obtained from kidney of Bactrian camel were treated with low glucose (LG) or high glucose (HG). The transcriptome gene expression in primary tubular epithelial cells of Bactrian camel was examined using RNA sequencing technology. 1322 genes from HG and LG were significantly altered. The up-regulated genes in the HG group include CAMK2B, CRYAA and VNN1. Several pathways associated with diabetic nephropathy including PI3K-Akt signaling pathway, AGE-RAGE signaling pathway, ECM-receptor interaction and PPAR signaling pathway were activated by HG stimulation. This study provides scientific basis for understanding the mechanism of renal tolerance to hyperglycemia of Bactrian camel.
Key words: Bactrian camel; high glucose; transcriptome; tubular epithelial cells 


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